تله‌اندازی خطی سلول‌های سرطانی با امواج صوتی

The study and investigation of micro-particles and biological samples has always been of interest. For this purpose, non-contact control of these particles and samples is of great importance. Recent studies have shown that the use of high-frequency standing acoustic waves, called acoustic tweezers, increased the trapping potential. The acoustic trap does not have the destructive effects of heat for biological samples that are in the trap, and the sample is biologically alive after trapping. Studies and tests show that the sonic tongs are biocompatible.
In this research, the aim is to linearly trap micro-particles and biological samples with standing acoustic waves for microscopic studies, for this purpose, an acoustic trap chamber was designed and built. The constructed acoustic trap has the ability to trap a group of particles linearly in one dimension. By changing the frequency and relative phase difference of the acoustic waves, the trapped samples are moved. The power of the trap is adjusted by changing the amplitude of the acoustic wave. In this study, silica micro-particles were used to check the quality of the trap. Multi-micron silica particles were linearly trapped in the acoustic pressure node. Also, breast cancer cells and skin cells in the culture medium were confined in pressure nodal lines. Destructive effects of heat were not observed after acoustic trapping and the bio-specimens remained biologically viable.